University of Wisconsin-Madison biochemist Karl Paul Link and his lab isolated an anticoagulant compound from spoiled sweet clover hay in 1939, after a Wisconsin farmer's cattle began hemorrhaging from the moldy feed. Their research led to warfarin, marketed first as a rat poison in 1948 and later approved as the blood-thinning drug warfarin sodium (Coumadin) in 1954. It remains one of the world's most widely prescribed anticoagulants.
Karl Paul Link
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Image Credit: The University of Wisconsin Collection, The American Chemical SocietyImage Caption: Mark A. Stahmann (left) and Karl Paul Link discovered dicumarol, a powerful anticoagulant. They are shown in 1940 in a UW-Madison biochemistry laboratory.2022
Courtesy of The University of Wisconsin Collection
Innovations
University of Wisconsin-Madison biochemist Karl Paul Link and his lab isolated an anticoagulant compound from spoiled sweet clover hay in 1939, after a Wisconsin farmer's cattle began hemorrhaging from the moldy feed. Their research led to warfarin, marketed first as a rat poison in 1948 and…
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