Medical

In the 1970s, microbiologist Satoshi Ōmura at Japan's Kitasato Institute isolated a soil bacterium that produced compounds effective against parasitic worms. Working under a partnership with Merck, parasitologist William C. Campbell's team refined these compounds into ivermectin, a veterinary treatment approved in 1981 and later adapted into Mectizan, approved for human use in 1987 to treat river blindness. Merck committed to donating Mectizan indefinitely to combat the disease, and Ōmura and Campbell shared the 2015 Nobel Prize in Physiology or Medicine for the discovery.

University of Wisconsin-Madison biochemist Karl Paul Link and his lab isolated an anticoagulant compound from spoiled sweet clover hay in 1939, after a Wisconsin farmer's cattle began hemorrhaging from the moldy feed. Their research led to warfarin, marketed first as a rat poison in 1948 and later approved as the blood-thinning drug warfarin sodium (Coumadin) in 1954. It remains one of the world's most widely prescribed anticoagulants.

The antihistamine Benadryl has provided temporary relief from allergy symptoms for millions of people since it was developed by George Rieveschl at a University of Cincinnati laboratory in the early 1940s and later approved by the U.S. Food and Drug Administration (FDA). Rieveschl was originally studying muscle relaxants when he discovered the compound diphenhydramine hydrochloride. He sold it under the name ‘Benadryl,’ among others.

The story is so improbable it defies belief: a soil sample from Japan stops suffering in Africa. It starts when a scientist discovers a lowly bacterium near a golf course outside Tokyo. A team of scientists in the United States finds that the bacterium produces compounds that impede the activity of nematode worms. It is developed into a drug that wards off parasites in countless pets and farm animals, averting billions of dollars in losses worldwide.

Monroe Wall, Mansukh Wani and colleagues at the Natural Products Laboratory of the Research Triangle Institute discovered and elucidated the structure Taxol®and camptothecin, two life-saving compounds for the treatment of cancer. These natural products kill cancer cells via unique mechanisms of action and in ways scientists had not previously imagined. The work of this research team led to the eventual development and marketing of drugs that have been approved for treatment of ovarian, breast, lung, and colon cancer and Kaposi’s sarcoma.

The introduction of penicillin in the 1940s, which began the era of antibiotics, has been recognized as one of the greatest advances in therapeutic medicine. The discovery of penicillin and the initial recognition of its therapeutic potential occurred in the United Kingdom, but, due to World War II, the United States played the major role in developing large-scale production of the drug, thus making a life-saving substance in limited supply into a widely available medicine.

The plaque commemorating the event reads:

It is difficult to recall a time when doctors and patients had trouble tracking the presence of glucose and other substances in urine and blood. Lack of sufficient measurement tools made it difficult to manage a host of diseases, including diabetes as well as other metabolic diseases and kidney and liver conditions. Today, self-management of these diseases is an easier process because of the development of diagnostic test strips by Alfred and Helen Free and their research team at Miles Laboratories.

The text of the plaque commemorating the development reads:

In brilliant collaboration, Carl and Gerty Cori studied how the body metabolizes glucose and advanced the understanding of how the body produces and stores energy. Their findings were particularly useful in the development of treatments for diabetes. In 1947 the Coris shared a Nobel Prize for their discoveries.

The plaque commemorating the event reads:

Steroid chemists often refer to the 1930s as the Decade of the Sex Hormones, when the molecular structures of certain sex hormones were determined and first introduced to medical practice as drugs. Russell Marker achieved the first practical synthesis of the pregnancy hormone, progesterone, by what now is known as the "Marker Degradation." Produced from starting material in a species of Mexican yam, Marker’s progesterone eventually became the preferred precursor in the industrial preparation of the anti-inflammatory drug cortisone.