Biomedical Research

Trials of the new product were launched in the 1950s at Indiana University (IU), in Bloomington. There, a dentist instructed children to brush their teeth — in whichever way they normally did — with a new kind of paste. After six months, the kids came back for a checkup. These local children were not just dental patients, they were participants in one of the biggest clinical trials ever run on toothpaste. The main investigator in this endeavor was Dr. Joseph Muhler, a dentist and assistant professor in the university’s chemistry department.

The antihistamine Benadryl has provided temporary relief from allergy symptoms for millions of people since it was developed by George Rieveschl at a University of Cincinnati laboratory in the early 1940s and later approved by the U.S. Food and Drug Administration (FDA). Rieveschl was originally studying muscle relaxants when he discovered the compound diphenhydramine hydrochloride. He sold it under the name ‘Benadryl,’ among others.

For more than a century, scientists at Rockefeller University have enhanced our understanding of the molecular basis of life — specifically the relationship between the structure and function of nucleic acids and proteins. They showed that DNA transfers genetic information and that the sugars ribose and deoxyribose are the key building blocks of the nucleic acids RNA and DNA.