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Wind dynamics were a major consideration in building such a huge structure. When winds blow against the building, they are deflected up over the roof, creating a partial vacuum that can draw the roof up with a force several times greater than the direct force of the wind. Wind tunnel testing on a model helped designers decide that a semi-parabolic shape would best resolve air current concerns.

Put in service in 1937, this world-renowned bridge, conceived by Joseph Strauss and designed largely by Charles Ellis, was the longest single span (4,200 feet) in the world for a quarter century.

As with many civil engineering projects in their conceptual stages, naysayers scoffed at the Golden Gate Bridge. They said it would be technically unfeasible or too expensive to bridge the Golden Gate, a 1.7-mile-wide opening separating the Pacific Ocean from the San Francisco Bay. They said that the channel was too deep; the tides and winds too strong; the span too long.

Considered one of the world's most scenic mountain drives, the two-lane Going-To-The-Sun Road through Glacier National Park was the first major road to be constructed directly over high mountain terrain, proving that roads did not need to be limited to mountain passes.

Gilman Hall, built in 1916-1917, accommodated a growing College of Chemistry by providing expanded research and teaching facilities for faculty and students specializing in physical, inorganic and nuclear chemistry. Work performed at Gilman Hall helped advance the fields of chemical thermodynamics and molecular structure, and has resulted in multiple Nobel Prizes. The Hall is most famous for the work of Glenn T. Seaborg and his coworkers, which included the successful identification and production the element Plutonium. Seaborg received the Nobel Prize in 1951 for his accomplishments.

The Georgetown Steam Plant, a surprisingly complete and operable steam power plant after a career of nearly seventy-five years, was built in the early 1900s when Seattle's inexpensive hydroelectric power attracted manufacturers. Much of the power produced at this plant operated the streetcars. It marks the beginning of the end of the reciprocating steam engine's domination in the growing field of electrical energy generation for lighting and power.

In 1961, in the National Institutes of Health Headquarters (Bethesda, MD), Marshall Nirenberg and Heinrich Matthaei discovered the key to breaking the genetic code when they conducted an experiment using a synthetic RNA chain of multiple units of uracil to instruct a chain of amino acids to add phenylalanine. The uracil (poly-U) served as a messenger directing protein synthesis. This experiment demonstrated that messenger RNA transcribes genetic information from DNA, regulating the assembly of amino acids into complex proteins.